According to the Centers for Disease Control, there are more than 9.5 million blood donors and 5 million patients who receive blood in the United States annually. This means that there are approximately 14.6 million blood transfusions each year. However, blood transfusion therapy is associated with certain inherent risks for the patient, such as infection and transfusion-transmitted diseases. Furthermore, with so many people involved and patients dependent upon these transfusions to maintain their health, it is extremely important that all healthcare professionals are aware of how to safely maintain and utilize blood products. This continuing education activity will review blood components in context of transfusion therapy, blood transfusions and key considerations in blood collection and testing to help nurses understand their roles in ensuring the safety of patients who receive blood and blood products.