Allergic reactions to natural rubber latex are significant health and occupational concerns. Latex allergy can be very limiting to some people. In some cases, it can even be life threatening. Therefore, effective strategies must be taken in the practice setting to identify patients and healthcare workers at risk and also to reduce exposure to natural rubber latex products. This activity will discuss what nurses need to know about identifying patients who are likely to be latex-sensitive and how to protect latex-sensitive patients and staff in the acute care setting. In addition, discussion will focus on what latex allergy is and what causes it, risk factors for latex allergy, different types of latex reactions, and what to do if you, a coworker, or a patient is allergic to latex.